Title
Constitutive synthesis of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1): Conditions and therapeutic targets
Author
Kluft, C.
TNO Preventie en Gezondheid
Publication year
1994
Abstract
In the population at large and in individual normal volunteers, baseline molar concentratios of t-PA and PAI-1 in plasma show a strong correlation. Evidence is summarized that insulin resistance is a prominent cause of interindividual variation, next to possible contributions of vascular inflammation and steroid hormones. In healthy volunteers, the coordinated elevation of both t-PA and PAI-1 in plasma is associated with a decrease in free, circulating, active t-PA. Evaluation of our knowledge about the mechanisms causing the observed coordinated appearance of t-PA and PAI-1, reveals basic deficiencies in knowledge about involvement of synthesis and clearance. Several independent epidemiological studies have shown that risk for cardiovascular events is associated with increased molar concentrations of t-PA or PAI-1, or with a decreased plasma t-PA activity. It is hypothesized that this represents a state of related increase in molar concentrations of t-PA and PAI-1, and that these risk indicators are interrelated. This hypothesis requires further validation in prospective epidemiological research in which all variables are studied simultaneously, with adequate methodology. Chemicals/CAS: plasminogen activator inhibitor 1, 140208-23-7; tissue plasminogen activator, 105913-11-9
Subject
Biology
fibrinolysis
plasminogen activator inhibitor type-1
risk markers
tissue-type plasminogen activator
plasminogen activator inhibitor 1
tissue plasminogen activator
cardiovascular disease
conference paper
fibrinolysis
human
risk factor
To reference this document use:
http://resolver.tudelft.nl/uuid:9d6334e3-c005-4da5-ac0c-c3ce29b79655
TNO identifier
232515
ISSN
0268-9499
Source
Fibrinolysis, 8 (SUPPL. 2), 1-7
Document type
article