Title
Seasonal variation in fibrinogen in the Rotterdam study
Author
van der Bom, J.G.
de Maat, M.P.M.
Bots, M.L.
Hofman, A.
Kluft, C.
Grobbee, D.E.
Gaubius Instituut TNO
Publication year
1997
Abstract
As evidence accumulates to implicate fibrinogen as a risk indicator for cardiovascular disease, it is of interest to study its seasonal variation. A population based cross-sectional study was performed among participants of the Rotterdam Study, a cohort of 7983 men and women, aged 55 years and over. Fibrinogen levels were measured by the prothrombin time derived method in the first 2325 participants of the study. Fibrinogen levels were considerably higher in winter. The seasonal difference was 0.34 g/l (95% confidence interval 0.29, 0.39) and was more pronounced in subjects aged 75 years and over than in subjects aged 55 to 75 years, 0.43 g/l (0.34, 0.52) and 0.29, g/l (0.24, 0.35), respectively. Additional adjustment for body mass index, systolic and diastolic blood pressure, and total and HDL cholesterol did not materially change the findings. After adjustment for seasons, outdoor temperature was not associated with fibrinogen. Adjustment for outdoor temperature did not change the seasonal variation of fibrinogen, seasonal difference 0.31 g/l (0.24, 0.37). In conclusion, fibrinogen levels are highest in Winter. The seasonal variation of fibrinogen is more pronounced in the elderly. Outdoor temperature does not seem to play a role in the seasonal variation of fibrinogen. Seasonal variation of fibrinogen may partly explain the increased cardiovascular disease mortality in Winter. Copyright © 1997 Schattauer Verlag
Subject
Biology
cholesterol
high density lipoprotein cholesterol
adult
age
body mass
cardiovascular disease
cholesterol blood level
controlled study
diastolic blood pressure
environmental temperature
fibrinogen blood level
human experiment
mortality
normal human
priority journal
prothrombin time
risk
seasonal variation
systolic blood pressure
winter
Adult
Aged
Aging
Body Mass Index
Cholesterol, HDL
Cohort Studies
Cross-Sectional Studies
Female
Fibrinogen
Humans
Male
Netherlands
Reference Values
Seasons
Temperature
To reference this document use:
http://resolver.tudelft.nl/uuid:92fdceb1-cb42-4be0-a4ce-3d08664792c1
DOI
https://doi.org/10.1055/s-0038-1657687
TNO identifier
234028
ISSN
0340-6245
Source
Thrombosis and Haemostasis, 78 (3), 1059-1062
Document type
article