Print Email Facebook Twitter Alcohol consumption, type of alcoholic beverage and risk of colorectal cancer at specific subsites Title Alcohol consumption, type of alcoholic beverage and risk of colorectal cancer at specific subsites Author Bongaerts, B.W.C. van den Brandt, P.A. Goldbohm, R.A. de Goeij, A.F.P.M. Weijenberg, M.P. TNO Kwaliteit van Leven Publication year 2008 Abstract Within the Netherlands Cohort Study on diet and cancer, we investigated associations between total alcohol consumption, specific alcoholic beverage consumption and risk of colorectal cancer (CRC) according to anatomical subsite. Hazard Ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models. Analyses were performed on 2,323 CRC cases, available after 13.3 years of follow-up. Compared to abstaining, alcohol consumption of ≥30.0 g/day (∼3 alcoholic drinks) was positively associated with the risk of CRC (HR: 1.32, 95% CI: 1.06-1.65). Analyses restricted to subjects who reported to have consumed equal amounts of alcohol 5 years before baseline compared to baseline, showed elevated risk estimates for consumers of ≥30.0 g of total alcohol per day as well (HR: 1.53, 95% CI: 1.16-2.01). Suggestive of a subsite-specific effect, cancer risk seemed to increase from proximal colon through rectum; HR: 1.29, 95% CI: 0.85-1.96 for proximal colon cancer, HR: 1.41, 95% CI: 0.94-2.11 for distal colon cancer, HR: 2.07, 95% CI: 1.03-4.18 for rectosigmoid cancer and HR: 1.69, 95% CI: 1.08-2.64 for rectal cancer. No associations were observed between consumption of alcoholic beverages and CRC risk when compared with the non-drinkers of the specific beverage and after adjustment for total alcohol intake. No evidence was found for sex-specific effects of alcohol and alcoholic beverages. In conclusion, our data showed a positive association between alcohol consumption and risk of CRC, which seemed to be mainly explained by the alcoholic content of alcoholic beverages, rather than other constituents. Also, cancer risk may vary according to anatomical subsite. © 2008 Wiley-Liss, Inc. Subject Healthy for LifeHealthHealthy LivingAlcoholAlcoholic beveragesCohort studyColorectal cancerThe Netherlandsalcoholadultagedalcohol abstinencealcohol consumptionalcoholic beveragearticleascending coloncancer localizationcancer riskcolon cancercolorectal cancercontrolled studydescending colondietdisease associationfemalefollow uphumanmaleNetherlandspriority journalrectum cancersex differencecohort analysiscolorectal tumordrinking behaviormiddle agedproportional hazards modelquestionnairerisk factorAgedAlcohol DrinkingAlcoholic BeveragesCohort StudiesColorectal NeoplasmsFemaleHumansMaleMiddle AgedNetherlandsProportional Hazards ModelsQuestionnairesRisk Factors To reference this document use: http://resolver.tudelft.nl/uuid:8c760b0f-f9f8-4431-a52e-3789ad791d7f DOI https://doi.org/10.1002/ijc.23774 TNO identifier 241124 ISSN 0020-7136 Source International Journal of Cancer, 123 (10), 2411-2417 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.