Title
Lipidomics reveals multiple pathway effects of a multi-components preparation on lipid biochemistry in ApoE*3Leiden.CETP mice
Author
Wei, H.
Hu, C.
Wang, M.
van den Hoek, A.M.
Reijmers, T.H.
Wopereis, S.
Bouwman, J.
Ramaker, R.
Korthout, H.A.A.J.
Vennik, M.
Hankemeier, T.
Havekes, L.M.
Witkamp, R.F.
Verheij, E.R.
Xu, G.
van der Greef, J.
Publication year
2012
Abstract
Background: Causes and consequences of the complex changes in lipids occurring in the metabolic syndrome are only partly understood. Several interconnected processes are deteriorating, which implies that multi-target approaches might be more successful than strategies based on a limited number of surrogate markers. Preparations from Chinese Medicine (CM) systems have been handed down with documented clinical features similar as metabolic syndrome, which might help developing new intervention for metabolic syndrome. The progress in systems biology and specific animal models created possibilities to assess the effects of such preparations. Here we report the plasma and liver lipidomics results of the intervention effects of a preparation SUB885C in apolipoprotein E3 Leiden cholesteryl ester transfer protein (ApoE*3Leiden.CETP) mice. SUB885C was developed according to the principles of CM for treatment of metabolic syndrome. The cannabinoid receptor type 1 blocker rimonabant was included as a general control for the evaluation of weight and metabolic responses. Methodology/Principal Findings: ApoE*3Leiden.CETP mice with mild hypercholesterolemia were divided into SUB885C-, rimonabant- and non-treated control groups. SUB885C caused no weight loss, but significantly reduced plasma cholesterol (-49%, p
Subject
EELS - Earth, Environmental and Life Sciences
Life
Healthy Living
Biomedical Innovation
Health Pharmacology
MHR - Metabolic Health Research MSB - Microbiology and Systems Biology RAPID - Risk Analysis for Products in Development
To reference this document use:
http://resolver.tudelft.nl/uuid:876089d5-4a7e-4de5-ab4e-6f72cb5be834
DOI
https://doi.org/10.1371/journal.pone.0030332
TNO identifier
446661
ISSN
1932-6203
Source
PLoS ONE, 7 (7)
Document type
article