Title
Urinary matrix metalloproteinase-8 and -9 activities in type 2 diabetic subjects: A marker of incipient diabetic nephropathy?
Author
van der Zijl, N.J.
Hanemaaijer, R.
Tushuizen, M.E.
Schindhelm, R.K.
Boerop, J.
Rustemeijer, C.
Bilo, H.J.
Verheijen, J.H.
Diamant, M.
TNO Kwaliteit van Leven
Publication year
2010
Abstract
Matrix metalloproteinases (MMPs) may play a pathophysiological role in the development of diabetic nephropathy (DN). We hypothesized that urinary MMP activity in patients with type 2 diabetes mellitus (T2DM) is related to a decline in renal function. We determined MMP-2, -8 and -9 activity in 24-h urine collections in relation to risk factors for DN in T2DM patients with (UA, n=27) and without albuminuria (NA, n=48) and controls (CO, n=28). MMP-8 and -9 levels were highest in UA patients (P<0.01). Of UA patients, 93% had at least one MMP increased, compared to 78% of NA patients and 46% of CO (P=0.001). Age, diabetes duration, BMI, systolic blood pressure, fasting plasma glucose, HbA1c and renal function were determinants of MMP-8 and -9 (P<0.05). In summary, MMP-8 and -9 are highest in T2DM UA patients. MMP-9, showed the strongest associations with clinical parameters related to DN. © 2010 The Canadian Society of Clinical Chemists.
Subject
Biology
Albuminuria
Diabetic nephropathy
MMP-2
MMP-8
MMP-9
Type 2 diabetes mellitus
To reference this document use:
http://resolver.tudelft.nl/uuid:81f2bfd4-65dd-49ca-996d-e273280e09f3
DOI
https://doi.org/10.1016/j.clinbiochem.2010.02.006
TNO identifier
347303
ISSN
0009-9120
Source
Clinical Biochemistry, 43 (7-8), 635-639
Document type
article