Print Email Facebook Twitter Body mass index, height and risk of adenocarcinoma of the oesophagus and gastric cardia: A prospective cohort study Title Body mass index, height and risk of adenocarcinoma of the oesophagus and gastric cardia: A prospective cohort study Author Merry, A.H.H. Schouten, L.J. Goldbohm, R.A. van den Brandt, P.A. TNO Kwaliteit van Leven Publication year 2007 Abstract Background: In the last decades, the incidence of oesophageal and gastric cardia adenocarcinoma has increased rapidly in the Western world. We investigated the association between body mass index (BMI), height and risk of oesophageal and gastric cardia adenocarcinoma. Methods: The Netherlands Cohort Study was initiated in 1986. All participants (n = 120 852), aged 55-69 years, completed a self administered questionnaire. Cases were identified through annual record linkage with the Netherlands Cancer Registry. After 13.3 years of follow-up, excluding the first follow-up year, complete data from 4552 subcohort members, 133 oesophageal and 163 gastric cardia adenocarcinomas were available for case-cohort analyses. Incidence rate ratios (RRs) and corresponding 95% confidence intervals were estimated using Cox proportional hazard models. Results: The RRs (95% CI) of oesophageal adenocarcinoma were 1.40 (0.95 to 2.04) and 3.96 (2.27 to 6.88) for overweight (BMI 25.0-29.9 kg/m2) and obese subjects (BMI ≥ 30.0 kg/m2), respectively, compared to subjects with normal weight (BMI 20.0-24.9 kg/m2). For gastric cardia adenocarcinoma, these RRs were 1.32 (0.94 to 1.85) and 2.73 (1.56 to 4.79). Also change in BMI during adulthood was positively associated with the risk of oesophageal and gastric cardia adenocarcinoma (p trend 0.001 and 0.02, respectively), while no association was found with BMI in early adulthood (p trend 0.17 and 0.17, respectively). None of the tumour types investigated was significantly associated with height. Conclusions: These results confirm higher risks of oesophageal and gastric cardia adenocarcinoma with increasing BMI. This implies that the increasing prevalence of obesity may be one of the explanations for the rising incidence of oesophageal and gastric cardia adenocarcinoma in the Western world. Subject HealthFood and Chemical Risk Analysisadultagedarticlebody masscancer riskcontrolled studydemographydisease associationesophageal adenocarcinomafemalefollow upheighthumanmajor clinical studymaleobesitypriority journalsquamous cell carcinomastomach carcinomaAdenocarcinomaAgedBody HeightBody Mass IndexCardiaEpidemiologic MethodsEsophageal NeoplasmsFemaleHumansMaleMiddle AgedNetherlandsObesityStomach Neoplasms To reference this document use: http://resolver.tudelft.nl/uuid:80d44f94-56d9-47c2-af5f-db5c990204a7 DOI https://doi.org/10.1136/gut.2006.116665 TNO identifier 240274 ISSN 0017-5749 Source Gut, 56 (11), 1503-1511 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.