Title
Alcohol intake and aortic stiffness in young men and women
Author
van den Elzen, A.P.
Sierksma, A.
Oren, A.
Vos, L.E.
Witteman, J.C.
Grobbee, D.E.
Hendriks, H.F.
Uiterwaal, C.S.
Bots, M.L.
TNO Kwaliteit van Leven
Publication year
2005
Abstract
Background: Moderate alcohol consumption has been shown to protect against cardiovascular disease. Aortic stiffness can be regarded as a marker of cardiovascular disease risk. Previously we have shown an inverse to J-shaped association between alcohol intake and aortic stiffness in middle-aged and elderly men and postmenopausal women. Objective: In the present study we examined whether a relation between alcohol intake and aortic stiffness is already present at a younger age. Design: Cross-sectional data of a cohort study in men and women aged 28 years were analysed stratified by gender (240 men and 283 women). Measurements: Alcohol intake was derived from a questionnaire and aortic stiffness was assessed by pulse-wave velocity measurement. Results: In women an alcoholic beverage intake of ≥1 glass/day is associated with a 0.36 m/s (95% confidence interval, -0.58 to -0.14) lower pulse-wave velocity compared with non-drinkers. In men alcohol intake is also inversely related to pulse-wave velocity, but this was not significant. These findings were independent of age, blood pressure and heart rate. Conclusions: These findings suggest that moderate intake of alcohol may affect vascular stiffness at an early age, notably in women. These findings may be viewed as compatible with a vascular protective effect of alcohol that expresses well before the occurrence of symptomatic cardiovascular disease. © 2005 Lippincott Williams & Wilkins.
Subject
Health
Biomedical Research
Alcohol
Aortic stiffness
Cardiovascular disease risk
Pulse-wave velocity
Young men and women
alcohol
adult
age
alcohol consumption
aorta disease
aorta stiffness
article
atherosclerosis
cardiovascular disease
cardiovascular risk
correlation analysis
disease association
female
gender
heart protection
heart rate
human
major clinical study
male
pathogenesis
postmenopause
priority journal
pulse wave
questionnaire
Adult
Age Distribution
Alcohol Drinking
Aortic Diseases
Blood Flow Velocity
Cohort Studies
Cross-Sectional Studies
Female
Humans
Hypertension
Male
Pulsatile Flow
Risk Factors
Sex Distribution
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TNO identifier
238414
ISSN
0263-6352
Source
Journal of Hypertension, 23 (4), 731-735
Document type
article