Title
Repeated exposure to acrolein vapour: Subacute studies in hamsters, rats and rabbits
Author
Feron, V.J.
Kruysse, A.
Til, H.P.
Immel, H.R.
Centraal instituut voor voedingsonderzoek TNO
Publication year
1978
Abstract
The subacute inhalation toxicity of acrolein was examined in 4 groups of 20 hamsters, 12 rats and 4 rabbits each, exposed repeatedly to acrolein vapour at concentrations of 0, 0.4, 1.4 and 4.9 ppm (6 hr/day, 5 days/week) for a 13-week period. The most important effects found at the highest level included mortality in rats, ocular and nasal irritation, growth depression and histopathological changes of the respiratory tract in each of the animal species exposed. The aberrations in the airways consisted of destruction and hyper- and metaplasia of the lining epithelium accompanied by inflammatory alterations. Rats appeared to be the most susceptible of the species examined and showed treatment-related abnormalities even at 0.4 ppm, whereas this exposure level was found to be a no-toxic effect level in both hamsters and rabbits. Chemicals/CAS: acrolein, 107-02-8; Acrolein, 107-02-8; Aerosols; Aldehydes
Subject
Animal experiment
Drug toxicity
Rye irritation
Growth inhibition
Histology
Inhalational drug administration
Intoxication
Microscopy
Nose
Respiratory system
Vapor
Acrolein
Aerosols
Aldehydes
Body Weight
Comparative Study
Eating
Growth
Hamsters
Mesocricetus
Organ Weight
Rabbits
Rats
Medicine
Geneeskunde
Pharmacology
Toxicology
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TNO identifier
228355
ISSN
0300-483X
Source
Toxicology, 9 (1-2), 47-57
Document type
article