Title
Omega-3 fatty acids in adipose tissue and risk of myocardial infarction: The EURAMIC study
Author
Guallar, E.
Aro, A.
Jiménez, F.J.
Martín-Moreno, J.M.
Salminen, I.
van 't Veer, P.
Kardinaal, A.F.M.
Gömez-Aracena, J.
Martin, B.C.
Kohlmeier, L.
Kark, J.D.
Mazaev, V.P.
Ringstad, J.
Guillén, J.
Riemersma, R.A.
Huttunen, J.K.
Thamm, M.
Kok, F.J.
Publication year
1999
Abstract
Omega-3 fatty acids have potential antiatherogenic, antithrombotic, and antiarrhythmic properties, but their role in coronary heart disease remains controversial. To evaluate the association of omega-3 fatty acids in adipose tissue with the risk of myocardial infarction in men, a case-control study was conducted in eight European countries and Israel. Cases (n=639) included patients with a first myocardial infarction admitted to coronary care units within 24 hours from the onset of symptoms. Controls (n=700) were selected to represent the populations originating the cases. Adipose tissue levels of fatty acids were determined by capillary gas chromatography. The mean (±SD) proportion of α-linolenic acid was 0.77% (±0.19) of fatty acids in cases and 0.80% (±0.19) of fatty acids in controls (P=0.01). The relative risk for the highest quintile of α-linolenic acid compared with the lowest was 0.42 (95% confidence interval [CI] 0.22 to 0.81, P-trend=0.02). After adjusting for classical risk factors, the relative risk for the highest quintile was 0.68 (95% CI 0.31 to 1.49, P-trend=0.38). The mean proportion of docosahexaenoic acid was 0.24% (±0.13) of fatty acids in cases and 0.25% (±0.13) of fatty acids in controls (P=0.14), with no evidence of association with risk of myocardial infarction. In this large case-control study we could not detect a protective effect of docosahexaenoic acid on the risk of myocardial infarction. The protective effect of α-linolenic acid was attenuated after adjusting for classical risk factors (mainly smoking), but it deserves further research.
Subject
α-linolenic acid
Adipose tissue
Case- control studies
Docosahexaenoic acid
Myocardial infarction
docosahexaenoic acid
linoleic acid
omega 3 fatty acid
adipose tissue
antiarrhythmic activity
article
atherogenesis
capillary gas chromatography
case control study
cell membrane
cigarette smoking
Europe
fatty acid metabolism
heart infarction
human
Israel
major clinical study
priority journal
risk assessment
risk factor
thrombosis
Adipose Tissue
Aged
Case-Control Studies
Europe
Fatty Acids, Omega-3
Humans
Male
Middle Aged
Myocardial Infarction
Random Allocation
Risk Factors
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TNO identifier
234986
ISSN
1079-5642
Source
Arteriosclerosis, Thrombosis, and Vascular Biology, 19 (4), 1111-1118
Document type
article