Title
Genetic analysis of sex and generation differences in plasma lipid, lipoprotein, and apolipoprotein levels in adolescent twins and their parents
Author
Boomsma, D.I.
Kempen, H.J.M.
Gevers Leuven, J.A.
Havekes, L.
de Knijff, P.
Frants, R.R.
TNO Preventie en Gezondheid
Publication year
1996
Abstract
In a sample of Dutch families consisting of parents aged 35-65 years and their twin offspring aged 14-21 years, a significant difference between generations was observed in phenotypic variances and in genetic heritabilities for plasma levels of total cholesterol, triglycerides, high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol, and apolipoproteins (apo) A1, A2, B, and E. For all traits parents were more variable than their offspring. This increase in phenotypic variance was best explained by a genetic model in which individual specific environmental variance increased with increasing age. Genetic variance was the same across generations for nearly all traits except triglycerides and apoE, for which a decrease in genetic variance was observed. This model led to large intergenerational differences in genetic heritabilities. Heritabilities for children were between 65 and 87%, while heritabilities for their parents were between 10 and 50%. No evidence was found for effects of a shared family environment.
Subject
Health
ApoA1
ApoA2
ApoB
ApoE
HDL
LDL
Adolescent
Adult
Age Distribution
Aged
Apolipoproteins
Cholesterol
Diseases in Twins
Female
Humans
Hyperlipidemias
Lipoproteins
Male
Middle Aged
Models, Genetic
Netherlands
Phenotype
Sex Distribution
Variation (Genetics)
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http://resolver.tudelft.nl/uuid:6e32cb76-5f6f-4322-ae4a-1fb447ec6567
DOI
https://doi.org/10.1002/(sici)1098-2272(1996)13:1<49::aid-gepi5>3.0.co;2-1
TNO identifier
233264
ISSN
0741-0395
Source
Genetic Epidemiology, 13 (1), 49-60
Document type
article