Print Email Facebook Twitter Apolipoprotein E phenotype is not related to late-life depression in a population-based sample Title Apolipoprotein E phenotype is not related to late-life depression in a population-based sample Author Schmand, B. Hooijer, C. Jonker, C. Lindeboom, J. Havekes, L.M. Gaubius instituut TNO Publication year 1998 Abstract Apolipoprotein E (ApoE) allele frequencies were examined in a population-based sample (n = 475; age range 65-84 years; Amsterdam Study of the Elderly). The relation of ApoE ε4 with dementia and with various types of late-life depression was studied. Depression was measured with the Geriatric Mental State schedule. Dementia was diagnosed by DSM-III-R criteria. It was expected that ApoE ε4 allele frequencies would be elevated not only in Alzheimer's disease and dementia in general, but also in first episode, late-life depression accompanied by subtle cognitive impairment (possibly organic depression). However, the results indicated that ε4 allele frequency is related to (family history of) dementia and cognitive impairment, but not to possibly organic depression. The main predictor of late-life depression is an episode of psychiatric problems before the age of 65 years. Subject HealthAgedAged, 80 and overAllelesAnalysis of VarianceApolipoproteins AChi-Square DistributionDepressionFemaleGenetics, PopulationHumansLikelihood FunctionsMaleNetherlandsPhenotypeRegression Analysis To reference this document use: http://resolver.tudelft.nl/uuid:6c2f988e-3ba8-4fa0-89c5-7d61cf43d31f DOI https://doi.org/10.1007/s001270050017 TNO identifier 234286 ISSN 0933-7954 Source Social Psychiatry and Psychiatric Epidemiology, 33 (1), 21-26 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.