Prediction of in vivo developmental toxicity of all‑trans‑retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling

Title

Prediction of in vivo developmental toxicity of all‑trans‑retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling

Author

Louisse, J.
Bosgra, S.
Blaauboer, B.J.
Rietjens, Y.M.C.M.
Verwei, M.

Publication year

2014

Subject

Life Triskelion BV
RAPID - Risk Assessment Products in Developmentv ARF - Analytical Research (Food)
ELSS - Earth, Life and Social Sciences TNO Bedrijven
Food and Nutrition
Toxicology
Healthy Living
All-trans-retinoic acid
Developmental toxicity
In vitro-in vivo extrapolation
Physiologically based kinetic modeling
Reverse dosimetry
Solid phase microextraction

To reference this document use:

http://resolver.tudelft.nl/uuid:5dcf8293-a15e-475e-a03a-d306496c7e1a

DOI

https://doi.org/10.1007/s00204-014-1289-4

TNO identifier

506928

Source

Reproductive Toxicology

Document type

article