Title
Microphysiological Systems to Recapitulate the Gut–Kidney Axis
Author
Giordano, L.
Mihaila, S.M.
Eslami Amirabadi, H.
Masereeuw, R.
Publication year
2021
Abstract
Chronic kidney disease (CKD) typically appears alongside other comorbidities, highlighting an underlying complex pathophysiology that is thought to be vastly modulated by the bidirectional gut–kidney crosstalk. By combining advances in tissue engineering, biofabrication, microfluidics, and biosensors, microphysiological systems (MPSs) have emerged as promising approaches for emulating the in vitro interconnection of multiple organs, while addressing the limitations of animal models. Mimicking the (patho)physiological states of the gut–kidney axis in vitro requires an MPS that can simulate not only this direct bidirectional crosstalk but also the contributions of other physiological participants such as the liver and the immune system. We discuss recent developments in the field that could potentially lead to in vitro modeling of the gut–kidney axis in CKD. © 2020 The Authors
Subject
Gut–kidney axis
Microphysiological systems
Remote signaling
Uremic toxins
Crosstalk
Physiology
Animal model
Biofabrication
Chronic kidney disease
Comorbidities
In-vitro
In-vitro models
Pathophysiology
Physiological state
Tissue engineering
To reference this document use:
http://resolver.tudelft.nl/uuid:54beb407-81a0-49d1-b86c-89c5b475b62b
DOI
https://doi.org/10.1016/j.tibtech.2020.12.001
TNO identifier
946707
ISSN
0167-7799
Source
Trends in Biotechnology, 39 (39), 811-823
Document type
article