Title
Decreased sensitivity to dexamethasone in lymphocytes from patients with Alzheimer's disease
Author
Nijhuis, E.
Hinloopen, B.
van Duijn, C.
Hofman, A.
Rozing, J.
Nagelkerken, L.
Section of Immunology, Inst. of Aging and Vascular Research, TNO, Leiden, Netherlands TNO Preventie en Gezondheid
Publication year
1994
Abstract
Cortisol levels in patients with Alzheimer's disease (AD) are relatively unaffected by a challenge with dexamethasone (DEX) in vivo. The present study demonstrates that DEX is less inhibitory for phytohemagglutinin (PHA)-induced T cell proliferation in AD patients as compared to age-matched controls. Since no significant differences were found between AD patients and age-matched controls with regard to the fraction of CD45RA+ or CD45RO+ CD4+ T cells nor the ability of peripheral blood mononuclear cells to produce IL-2 or IL-4, it is unlikely that the difference in DEX sensitivity is due to a changed lymphokine profile or a changed composition of the CD4+ T cell population. Sensitivity to DEX was negatively correlated with the ability to produce IL-2 and IL-4 in the controls but not in AD patients. This suggests that IL-2 and IL-4 synthesis in AD patients is less sensitive to regulation by glucocorticoids.
Subject
Health
cd4 antigen
dexamethasone
glucocorticoid
hydrocortisone
interleukin 2
interleukin 4
clinical article
clinical trial
controlled clinical trial
controlled study
Male
t lymphocyte subpopulation
Aged
Alzheimer Disease
Dexamethasone
Female
Humans
Lymphocyte Activation
Phenotype
Sensitivity and Specificity
T-Lymphocytes
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DOI
https://doi.org/10.1006/clin.1994.1168
TNO identifier
232696
ISSN
0090-1229
Source
Clinical Immunology and Immunopathology, 73 (1), 45-52
Document type
article