Print Email Facebook Twitter Changes in regional brain GFAP levels and behavioral functioning following subchronic lead acetate exposure in adult rats Title Changes in regional brain GFAP levels and behavioral functioning following subchronic lead acetate exposure in adult rats Author van den Berg, K.J. Lammers, J.H.C.M. Hoogendijk, E.M.G. Kulig, B.M. Centraal Instituut voor Voedingsonderzoek TNO Publication year 1996 Abstract Adult male WAG/Rij/MBL rats were dosed with lead acetate at 0, 4.0, 8.0 or 12.5 mg/kg, 5 days per week for 4 weeks. Animals were assessed prior to exposure, at the end of the 4-week exposure period and after a 2-week recovery period using a functional observational battery (FOB) and motor activity assessment. Rats were sacrificed two weeks after the last test session and glial fibrillary acidic protein (GFAP) concentrations were measured in eight selected brain regions. A dose-dependent decrease in motor activity was observed immediately following the end of the exposure period with no differences observed 2 weeks after cessation of exposure. Alterations in gait, decreased fore-and hindlimb grip strength, and decreased arousal were also found. Behavioral changes were accompanied by reduced weight gain and decreased body temperature during the course of exposure. GFAP concentrations were elevated in the frontal cortex, occipital cortex, striatum and hippocampus but not in thalamus, cerebellum or brain stem. These results indicate that lead causes functional effects in the adult rat which can be detected by neurobehavioral methods. Furthermore, region-specific alterations in brain GFAP concentrations provided evidence of specificity of lead neurotoxicity in the adult brain. Subject NutritionAdult RatsBrainGFAPLeadNeurobehaviorglial fibrillary acidic proteinlead acetateanimal behavioranimal experimentanimal tissuearousalbrain homogenateconference papercontrolled studydose time effect relationgaitgrip strengthhindlimblong term exposuremalemotor activityneurotoxicitynonhumanpriority journalprotein determinationratweight gainAnimalsBehavior, AnimalBrainGlial Fibrillary Acidic ProteinMaleOrganometallic CompoundsRatsRats, WistarTime FactorsAnimalia To reference this document use: http://resolver.tudelft.nl/uuid:4d87b9f7-a3de-4128-b8c2-dfeef5dd8f6e TNO identifier 233602 ISSN 0161-813X Source NeuroToxicology, 17 (3-4), 725-734 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.