Title
Serum and urinary biochemical markers for knee and hip-osteoarthritis: A systematic review applying the consensus BIPED criteria
Author
van Spil, W.E.
de Groot, J.
Lems, W.F.
Oostveen, J.C.M.
Lafeber, F.P.J.G.
TNO Kwaliteit van Leven
Publication year
2010
Abstract
Context: Molecules that are released into biological fluids during matrix metabolism of articular cartilage, subchondral bone, and synovial tissue could serve as biochemical markers of the process of osteoarthritis (OA). Unfortunately, actual breakthroughs in the biochemical OA marker field are limited so far. Objective: By reviewing the status of commercially available biochemical OA markers according to the "Burden of disease, Investigative, Prognostic, Efficacy of intervention, and Diagnostic" ("BIPED") classification, future use of this "BIPED" classification is encouraged and more efficient biochemical OA marker research stimulated. Data sources: Three electronic databases [PubMed, Scopus, EMBASE (1997-May 2009)] were searched for publications on blood and urinary biochemical markers in human primary knee and hip-OA. Study selection: Stepwise selection of original English publications describing human studies on blood or urinary biochemical markers in primary knee or hip-OA was performed. Selected articles were fully read to determine whether biochemical markers were investigated on performance within any of the "BIPED" categories. Eighty-four relevant publications were identified. Data extraction: Data from relevant publications were tabulated according to the "BIPED" classification. Individual analyses within a publication were summarized in general "BIPED" scores. Data synthesis: An uneven distribution of scores on biochemical marker performance and heterogeneity among the publications complicated direct comparison of individual biochemical markers. Comparison of categories of biochemical markers was therefore performed instead. In general, biochemical markers of cartilage degradation were investigated most extensively and performed well in comparison with other categories of biochemical markers. Biochemical markers of bone metabolism performed less adequately. Biochemical markers of synovial tissue metabolism were not investigated extensively, but performed quite well. Conclusions: Specific biochemical markers and categories of biochemical markers as well as their nature, origin and metabolism, need further investigation. International standardization of future investigations should be pursued to obtain more high-quality, homogenous data on the full spectrum of biochemical OA markers. © 2010 Osteoarthritis Research Society International.
Subject
Biology
Biomedical Research
Biochemical markers
Biomarkers
BIPED classification
Osteoarthritis
bone sialoprotein
cartilage oligomeric matrix protein
chondroitin sulfate
collagen type 1
collagen type 2
deoxypyridinoline
hyaluronic acid
keratan sulfate
osteocalcin
pentosidine
pyridinoline
risedronic acid
blood analysis
bone metabolism
cartilage degeneration
collagen synthesis
diagnostic value
disease severity
hip osteoarthritis
knee osteoarthritis
prognosis
synovium
systematic review
treatment response
urinalysis
To reference this document use:
http://resolver.tudelft.nl/uuid:4c512a07-ba1a-4182-823d-5341ddf277aa
TNO identifier
360838
ISSN
1063-4584
Source
Osteoarthritis and Cartilage, 18 (5), 605-612
Document type
article