Title
Establishing reporting standards for metabolomic and metabonomic studies: A call for participation
Author
Fiehn, O.
Kristal, B.
van Ommen, B.
Sumner, L.W.
Sansone, S.-A.
Taylor, C.
Hardy, N.
Kaddurah-Daouk, R.
TNO Kwaliteit van Leven
Publication year
2006
Abstract
Metabolite concentrations in cellular systems are very much dependent on the physiological, environmental, and genetic status of an organism and are regarded as the ultimate result of cellular regulation, resulting in the visible phenotypes. Therefore, the comprehensive analysis of metabolite levels and fluxes renders a suitable tool for assessing the degree of perturbation in biological systems. Lessons derived from development of other OMICS areas (genomics, proteomics, and transcriptomics) have shown that large-scale comparisons and interpretations will require the re-use of data over long periods of time and by multiple laboratories with different expertise and backgrounds. Reaching this goal will require standardization of reporting structures of metabolomic studies for journal publication purposes, for regulatory deposition, and for database dissemination. An initiative by the Metabolomics Society is presented that aims to define important aspects of metabolomic workflows. These include biological study designs, chemical analysis, and data processing, as well as the ontologies that are necessary in this framework. © Mary Ann Liebert, Inc.
Subject
Health
Biomedical Research
chemical analysis
data analysis
metabolite
metabolomics
metabonomics
priority journal
publication
research
review
standard
Animals
Databases, Factual
Humans
Metabolism
Research Design
Societies, Medical
Vocabulary, Controlled
To reference this document use:
http://resolver.tudelft.nl/uuid:4c0ff798-a3aa-4777-91d6-6dad171c39c5
DOI
https://doi.org/10.1089/omi.2006.10.158
TNO identifier
239475
ISSN
1536-2310
Source
OMICS A Journal of Integrative Biology, 10 (2), 158-163
Document type
article