Print Email Facebook Twitter Some effects of an ACTH 4-9 analog (Org 2766) on human performance Title Some effects of an ACTH 4-9 analog (Org 2766) on human performance Author Gaillard, A.W.K. Varey, C.A. Instituut voor Zintuigfysiologie TNO Publication year 1979 Abstract The effects (on human beings) of the ACTH analog Org 2766 were investigated for a range of performance tests: complicated serial reaction task, running memory span, verbal learning and non-verbal mental ability tests (closure flexibility and non-verbal abstraction). Subjective ratings on feeling were taken and heart rate was measured. Only the 30-min reaction task produced significant drug effects. In this task, performance tends to deteriorate as a function of time on task. During the test period there is a gradual increase in the number of lapses in performance due to moments of inattention. This deterioration is counteracted by the ACTH 4-9 analog, a result also found in a previous study using ACTH 4-10 (Org 0163). Thus ACTH fragments which are devoid of endocrine effects seem to have a beneficial effect on goal-directed motivation oriented on the requirements of the task. Chemicals/CAS: 2 amino 4 (methylsulfonyl)butyrylglutamylhistidylphenylalanyl dextro lysylphenylalanine, 50913-82-1; corticotropin[4-10], 4037-01-8; Corticotropin, 9002-60-2 Subject 2 amino 4 (methylsulfonyl)butyrylglutamylhistidylphenylalanyl dextro lysylphenylalanineCorticotropin derivativeCorticotropin[4-10]Org oi63PlaceboUnclassified drugCentral nervous systemCorticotropin[4-9]Drug efficacyHeartHuman cellNormal humanOral drug administrationPerformancePsychological aspectTherapyTouchCorticotropinEmotionsFemaleHeart RateHumanMaleMemoryMotivationPsychological TestsReaction TimeTime FactorsVerbal Learning To reference this document use: http://resolver.tudelft.nl/uuid:4a32face-0817-451a-b27e-b0180c0a86f8 DOI https://doi.org/10.1016/0031-9384(79)90126-4 TNO identifier 5092 Source Physiological Behaviour, 23 (1), 79-84 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.