Print Email Facebook Twitter Biological and Tribological Assessment of Poly(Ethylene Oxide Terephthalate)/Poly(Butylene Terephthalate), Polycaprolactone, and Poly (L\DL) Lactic Acid Plotted Scaffolds for Skeletal Tissue Regeneration Title Biological and Tribological Assessment of Poly(Ethylene Oxide Terephthalate)/Poly(Butylene Terephthalate), Polycaprolactone, and Poly (L\DL) Lactic Acid Plotted Scaffolds for Skeletal Tissue Regeneration Author Hendrikson, W.J. Zeng, X. Rouwkema, J. van Blitterswijk, C.A. van der Heide, E. Moroni, L. Publication year 2016 Abstract Additive manufactured scaffolds are fabricated from three commonly used biomaterials, polycaprolactone (PCL), poly (L\DL) lactic acid (P(L\DL)LA), and poly(ethylene oxide terephthalate)/poly(butylene terephthalate) (PEOT/PBT). Scaffolds are compared biologically and tribologically. Cell-seeded PEOT/PBT scaffolds cultured in osteogenic and chondrogenic differentiation media show statistical significantly higher alkaline phosphatase (ALP) activity/DNA and glycosaminoglycans (GAG)/DNA ratios, followed by PCL and P(L\DL)LA scaffolds, respectively. The tribological performance is assessed by determining the friction coefficients of the scaffolds at different loads and sliding velocities. With increasing load or decreasing sliding velocity, the friction coefficient value decreases. PEOT/PBT show to have the lowest friction coefficient value, followed by PCL and P(L\DL)LA. The influence of the scaffold architecture is further determined with PEOT/PBT. Reducing of the fiber spacing results in a lower friction coefficient value. The best and the worst performing scaffold architecture are chosen to investigate the effect of cell culture on the friction coefficient. Matrix deposition is low in the cell-seeded scaffolds and the effect is, therefore, undetermined. Taken together, our studies show that PEOT/PBT scaffolds support better skeletal differentiation of seeded stromal cells and lower friction coefficient compared to PCL and P(L/DL)A scaffolds. cop. 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Subject Nano TechnologyMAS - Materials SolutionsTS - Technical SciencesHealthIndustrial InnovationFriction coefficientPCLPEOT/PBTScaffold architecture To reference this document use: http://resolver.tudelft.nl/uuid:47d8d22c-9934-4443-a788-7a22d4ea5600 DOI https://doi.org/10.1002/adhm.201500067 TNO identifier 532864 Publisher Wiley-VCH Verlag ISSN 2192-2640 Source Advanced Healthcare Materials, 5 (2), 232-243 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.