Title
Biological and Tribological Assessment of Poly(Ethylene Oxide Terephthalate)/Poly(Butylene Terephthalate), Polycaprolactone, and Poly (L\DL) Lactic Acid Plotted Scaffolds for Skeletal Tissue Regeneration
Author
Hendrikson, W.J.
Zeng, X.
Rouwkema, J.
van Blitterswijk, C.A.
van der Heide, E.
Moroni, L.
Publication year
2016
Abstract
Additive manufactured scaffolds are fabricated from three commonly used biomaterials, polycaprolactone (PCL), poly (L\DL) lactic acid (P(L\DL)LA), and poly(ethylene oxide terephthalate)/poly(butylene terephthalate) (PEOT/PBT). Scaffolds are compared biologically and tribologically. Cell-seeded PEOT/PBT scaffolds cultured in osteogenic and chondrogenic differentiation media show statistical significantly higher alkaline phosphatase (ALP) activity/DNA and glycosaminoglycans (GAG)/DNA ratios, followed by PCL and P(L\DL)LA scaffolds, respectively. The tribological performance is assessed by determining the friction coefficients of the scaffolds at different loads and sliding velocities. With increasing load or decreasing sliding velocity, the friction coefficient value decreases. PEOT/PBT show to have the lowest friction coefficient value, followed by PCL and P(L\DL)LA. The influence of the scaffold architecture is further determined with PEOT/PBT. Reducing of the fiber spacing results in a lower friction coefficient value. The best and the worst performing scaffold architecture are chosen to investigate the effect of cell culture on the friction coefficient. Matrix deposition is low in the cell-seeded scaffolds and the effect is, therefore, undetermined. Taken together, our studies show that PEOT/PBT scaffolds support better skeletal differentiation of seeded stromal cells and lower friction coefficient compared to PCL and P(L/DL)A scaffolds. cop. 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Subject
Nano Technology
MAS - Materials Solutions
TS - Technical Sciences
Health
Industrial Innovation
Friction coefficient
PCL
PEOT/PBT
Scaffold architecture
To reference this document use:
http://resolver.tudelft.nl/uuid:47d8d22c-9934-4443-a788-7a22d4ea5600
DOI
https://doi.org/10.1002/adhm.201500067
TNO identifier
532864
Publisher
Wiley-VCH Verlag
ISSN
2192-2640
Source
Advanced Healthcare Materials, 5 (2), 232-243
Document type
article