Title
Biological clearance of TEGDMA in guinea pigs
Author
Reichl, F.X.
Durner, J.
Kunzelmann, K.H.
Hickel, R.
Spahl, W.
Hume, W.R.
Moes, G.W.H
Kehe, K.
Walther, U.
Forth, W.
Publication year
2001
Abstract
The excretion of the dental composite component triethylene glycol dimethacrylate (TEGDMA) in feces and urine in vivo and, using the pendular perfusion technique with segments of jejunum and colon, the biliary and enteric excretion in situ were investigated in anesthetized guinea pigs. In the in situ experiments guinea pigs (n=4) received TEGDMA (0.02 mmol/kg body weight labelled with a tracer dose 14C-TEGDMA 0.7 kBq/g body weight) injected into the jugular vein. In the in vivo experiments guinea pigs (n=4) received TEGDMA (+ 14C-TEGDMA; same dose as above) via a gastric tube. Urine and feces were collected for 24 h. In the in situ experiments organs were removed from the guinea pigs 60 min after the beginning of the experiment, and the 14C radioactivity measured. During the 60-min perfusion period the calculated amount of 14C radioactivity excreted into the total jejunum and colon was 0.9±0.2% and 1.9±0.1% of the dose administered, respectively (means±SEM). Of the 14C-TEGDMA dose, 3.7±0.2% was found in the bile. A significantly (P
Subject
14C-TEGDMA
Blood
Clearance
Guinea pig
Urine
Carbon 14
Methacrylic acid derivative
Unclassified drug
Animal experiment
Animal model
Animal tissue
Body weight
Clearance
Colon
Controlled study
Dose response
Excretion
Feces analysis
Jejunum
Jugular vein
Kidney
Male
Muscle
Nonhuman
Radioactivity
Toxicity testing
Urinalysis
Animals
Bile
Breath tests
Carbon dioxide
Composite Resins
Injections, Intravenous
Metabolic clearance rate
Perfusion
Polyethylene glycols
Polymethacrylic acids
Time factors
Tissue distribution
Animalia
Cavia
Cavia porcellus
Dioxide, 124-38-9
Composite resins
Polyethylene glycols
triethylene glycol dimethacrylate, 109-16-0
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http://resolver.tudelft.nl/uuid:47507400-cfac-4a22-b2ff-8a05eb52d5c1
DOI
https://doi.org/10.1007/s002040000159
TNO identifier
236031
ISSN
0340-5761
Source
Archives of Toxicology, 75 (75), 22-27
Document type
article