Title
Pooled analysis of prospective cohort studies on height, weight and breast cancer risk
Author
van den Brandt, P.A.
Spiegelman, D.
Yaun, S-S.
Adami, H-O.
Beeson, L.
Folsom, A.R.
Fraser, G.
Goldbohm, R.A.
Graham, S.
Kushi, L.
Marshall, J.R.
Miller, A.B.
Rohan, T.
Smith-Warner, S.A.
Speizer, F.E.
Willett, W.C.
Wolk, A.
Hunter, D.J.
Centraal Instituut voor Voedingsonderzoek TNO
Publication year
2000
Abstract
The association between anthropometric indices and the risk of breast cancer was analyzed using pooled data from seven prospective cohort studies. Together, these cohorts comprise 337,819 women and 4,385 incident invasive breast cancer cases. In multivariate analyses controlling for reproductive, dietary, and other risk factors, the pooled relative risk (RR) of breast cancer per height increment of 5 cm was 1.02 (95% confidence interval (Cl): 0.96, 1.10) in premenopausal women and 1.07 (95% Cl: 1.03, 1.12) in postmenopausal women. Body mass index (BMI) showed significant inverse and positive associations with breast cancer among pre- and postmenopausal women, respectively; these associations were nonlinear. Compared with premenopausal women with a BMI of less than 21 kg/m2, women with a BMI exceeding 31 kg/m2 had an RR of 0.54 (95% Cl: 0.34, 0.85). In postmenopausal women, the RRs did not increase further when BMI exceeded 28 kg/m2; the RR for these women was 1.26 (95% Cl: 1.09, 1.46). The authors found little evidence for interaction with other breast cancer risk factors. Their data indicate that height is an independent risk factor for postmenopausal breast cancer; in premenopausal women, this relation is less clear. The association between BMI and breast cancer varies by menopausal status. Weight control may reduce the risk among postmenopausal women.
Subject
Nutrition
Body height
Body weight
Breast neoplasms
Prospective studies
Adult
Aged
Anthropometric parameters
Body height
Body mass
Breast cancer
Cancer risk
Clinical trial
Controlled clinical trial
Controlled study
Female
Human
Major clinical study
Multicenter study
Postmenopause
Premenopause
Weight reduction
Adult
Aged
Aged, 80 and over
Body Height
Body Weight
Breast Neoplasms
Cohort Studies
Female
Humans
Middle Aged
Multivariate Analysis
Postmenopause
Premenopause
Prospective Studies
Regression Analysis
Risk Factors
To reference this document use:
http://resolver.tudelft.nl/uuid:42038ab4-0527-4009-8127-e55ff61b532e
DOI
https://doi.org/10.1093/aje/152.6.514
TNO identifier
56881
ISSN
0002-9262
Source
American Journal of Epidemiology, 152 (6), 514-527
Document type
article