Title
Different human gut models reveal the distinct fermentation patterns of arabinoxylan versus inulin
Author
van den Abbeele, P.
Venema, K.
van de Wiele, T.
Verstraete, W.
Possemiers, S.
Publication year
2013
Abstract
Different in vitro models have been developed to assess how food compounds affect the human gut microbiota. Using two such models (SHIME(R) and TIM-2), we compared how long-chain arabinoxylan (LC-AX), a wheat-derived potentially prebiotic fiber, and inulin (IN), a well-established prebiotic compound, modulate SCFA production and bifidobacteria composition. While both the SHIME and TIM-2 differ in experimental design, they both demonstrated that LC-AX and IN specifically increased the health-promoting metabolites propionate and butyrate, respectively. Furthermore, LC-AX stimulated Bifidobacterium longum, while IN stimulated other bifidobacteria including Bifidobacterium adolescentis. The SHIME experiment also revealed that effects of LC-AX were more persistent during the 2-week wash-out period. These results confirm a recent in vivo study, during which humanized rats were treated with the same LC-AX/IN. In conclusion, results from different human gut models suggest that, besides IN, LC-AX are promising prebiotic candidates with high specificity toward Bifidobacterium longum and a selective propionate increase. © 2013 American Chemical Society.
Subject
Life
QS - Quality & Safety
EELS - Earth, Environmental and Life Sciences
Biomedical Innovation
Biology
Healthy Living
Bifidobacterium adolescentis
Bifidobacterium longum
Bowel
Fructans
High specificity
Human gut microbiota
Intestine
Microflora
Polysaccharides
Volatile fatty acids
Bacteria
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DOI
https://doi.org/10.1021/jf4021784
TNO identifier
482979
ISSN
0021-8561
Source
Journal of Agricultural and Food Chemistry, 61 (41), 9819-9827
Document type
article