Title
The etiology of uterine sarcomas: A pooled analysis of the epidemiology of endometrial cancer consortium
Author
Felix, A.S.
Cook, L.S.
Gaudet, M.M.
Rohan, T.E.
Schouten, L.J.
Setiawan, V.W.
Wise, L.A.
Anderson, K.E.
Bernstein, L.
de Vivo, I.
Friedenreich, C.M.
Gapstur, S.M.
Goldbohm, R.A.
Henderson, B.
Horn-Ross, P.L.
Kolonel, L.
Lacey, J.V.
Liang, X.
Lissowska, J.
Magliocco, A.
McCullough, M.L.
Miller, A.B.
Olson, S.H.
Palmer, J.R.
Park, Y.
Patel, A.V.
Prescott, J.
Rastogi, R.
Robien, K.
Rosenberg, L.
Schairer, C.
Ou Shu, X.
van den Brandt, P.A.
Virkus, R.A.
Wentzensen, N.
Xiang, Y.B.
Xu, W.H.
Yang, H.P.
Brinton, L.A.
Publication year
2013
Abstract
Background: Uterine sarcomas are characterised by early age at diagnosis, poor prognosis, and higher incidence among Black compared with White women, but their aetiology is poorly understood. Therefore, we performed a pooled analysis of data collected in the Epidemiology of Endometrial Cancer Consortium. We also examined risk factor associations for malignant mixed mullerian tumours (MMMTs) and endometrioid endometrial carcinomas (EECs) for comparison purposes. Methods: We pooled data on 229 uterine sarcomas, 244 MMMTs, 7623 EEC cases, and 28 829 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) for risk factors associated with uterine sarcoma, MMMT, and EEC were estimated with polytomous logistic regression. We also examined associations between epidemiological factors and histological subtypes of uterine sarcoma. Results: Significant risk factors for uterine sarcoma included obesity (body mass index (BMI)≥30 vs BMI
Subject
BSS - Behavioural and Societal Sciences
Human
Healthy Living
Healthy for Life
Health
LS - Life Style
To reference this document use:
http://resolver.tudelft.nl/uuid:3ff4cdf9-0399-466d-8b74-20c7d5cd78ef
DOI
https://doi.org/10.1038/bjc.2013.2
TNO identifier
471071
ISSN
0007-0920
Source
British Journal of Cancer, 108 (108), 727-734
Document type
article