Title
Associations between unprocessed red and processed meat, poultry, seafood and egg intake and the risk of prostate cancer: A pooled analysis of 15 prospective cohort studies
Author
Wu, K.
Spiegelman, D.
Hou, T.
Albanes, D.
Allen, N.E.
Berndt, S.I.
van den Brandt, P.A.
Giles, G.G.
Giovannucci, E.
Goldbohm, R.A.
Goodman, G.G.
Goodman, P.J.
Håkansson, N.
Inoue, M.
Key, T.J.
Kolonel, L.N.
Männistö, S.
McCullough, M.L.
Neuhouser, M.L.
Park, Y.
Platz, E.A.
Schenk, J.M.
Sinha, R.
Stampfer, M.J.
Stevens, V.L.
Tsugane, S.
Visvanathan, K.
Wilkens, L.R.
Wolk, A.
Ziegler, R.G.
Smith-Warner, S.A.
Publication year
2016
Abstract
Reports relating meat intake to prostate cancer risk are inconsistent. Associations between these dietary factors and prostate cancer were examined in a consortium of 15 cohort studies. During follow-up, 52,683 incident prostate cancer cases, including 4,924 advanced cases, were identified among 842,149 men. Cox proportional hazard models were used to calculate study-specific relative risks (RR) and then pooled using random effects models. Results do not support a substantial effect of total red, unprocessed red and processed meat for all prostate cancer outcomes, except for a modest positive association for tumors identified as advanced stage at diagnosis (advanced(r)). For seafood, no substantial effect was observed for prostate cancer regardless of stage or grade. Poultry intake was inversely associated with risk of advanced and fatal cancers (pooled multivariable RR [MVRR], 95% confidence interval, comparing ≥45 vs. <5 g/day: advanced 0.83, 0.70-0.99; trend test p value 0.29), fatal, 0.69, 0.59-0.82, trend test p value 0.16). Participants who ate ≥25 versus <5 g/day of eggs (1 egg 50 g) had a significant 14% increased risk of advanced and fatal cancers (advanced 1.14, 1.01-1.28, trend test p value 0.01; fatal 1.14, 1.00-1.30, trend test p value 0.01). When associations were analyzed separately by geographical region (North America vs. other continents), positive associations between unprocessed red meat and egg intake, and inverse associations between poultry intake and advanced, advanced(r) and fatal cancers were limited to North American studies. However, differences were only statistically significant for eggs. Observed differences in associations by geographical region warrant further investigation. © 2015 UICC.
Subject
Life
CH - Child Health
ELSS - Earth, Life and Social Sciences
Healthy for Life
Health
Healthy Living
Diet
Egg
Poultry
Processed meat
Prostate cancer
Seafood
Unprocessed red meat
To reference this document use:
http://resolver.tudelft.nl/uuid:393e8514-9ee7-4252-aa86-36df3b98eeb2
DOI
https://doi.org/10.1002/ijc.29973
TNO identifier
534107
ISSN
0020-7136
Source
International Journal of Cancer, 138 (10), 2368-2382
Document type
article