Identification and toxicological evaluation of chlorinated dibenzofuran and chlorinated naphthalene in two commercial polychlorinated biphenyls
Centraal Instituut voor Voedingsonderzoek TNO
van der Maas, H.L.
ten Noever de Brauw, M.C.
de Vos, R.H.
In a previous study (Vos & Koeman, Toxic. appl. Pharmac. 1970. In press) a significant difference in toxicity was found between three commercial polychlorinated biphenyl (PCB) preparations, high mortality, liver necrosis and chick oedema-like lesions being associated with only two of the compounds tested. In the present study, column and gas chromatography demonstrated the presence of polar compounds in the 25% diethyl ether fraction of each of these two PCB preparations, and a chick-embryo assay confirmed the high toxicity of this fraction. The polar compounds were not found in the corresponding fraction of the third PCB preparation; neither did this preparation have a significantly toxic effect on the chick embryo. Subsequent mass spectrometric and microcoulometric analyses indicated the identity of the polar compounds, which included tetra- and pentachlorodibenzofuran. The significance of these impurities is discussed. It is concluded that evaluation of animal tests on PCB is made extremely difficult by the presence of chlorinated dibenzofurans in some commercial PCB preparations. © 1970 Pergamon Press. Chemicals/CAS: chlorine, 13981-72-1, 7782-50-5; Benzofurans; Biphenyl Compounds; Chlorine, 7782-50-5
To reference this document use:
Food and Cosmetics Toxicology, 8 (8), 625-633