Title
Interleukin 10: A new risk marker for the development of restenosis after percutaneous coronary intervention
Author
Monraats, P.S.
Kurreeman, F.A.S.
Pons, D.
Sewgobind, V.D.K.D.
de Vries, F.R.
Zwinderman, A.H.
de Maat, M.P.M.
Doevendans, P.A.
de Winter, R.J.
Tio, R.A.
Waltenberger, J.
Huizinga, T.W.J.
Eefting, D.
Quax, P.H.A.
Frants, R.R.
van der Laarse, A.
van der Wall, E.E.
Jukema, J.W.
TNO Kwaliteit van Leven
Publication year
2007
Abstract
Genetic factors appear to be important in the process of restenosis after percutaneous coronary intervention (PCI), as well as in inflammation, a pivotal factor in restenosis. An important mediator in the inflammatory response is interleukin (IL)-10. Our aim was to study whether genetic variants in IL-10 predispose to the risk of restenosis. The GENetic DEterminants of Restenosis (GENDER) study included 3104 patients treated with successful PCI. Target vessel revascularization (TVR) was chosen as primary end point. Genotyping of the -2849G/A, -1082G/A, -592C/A and +4259A/G polymorphisms of the IL-10 gene was performed by MassArray platform. After adjusting for clinical variables, three polymorphisms significantly increased the risk of restenosis (-2849AA: relative risk (RR), 1.7, 95% confidence interval (CI), 1.2-2.5; -1082AA: RR, 1.4, 95% CI, 1.1-1.8 and +4259GG: RR, 2.0, 95% CI, 1.4-2.8). To further exclude possible involvement of neighboring genes due to LD in the IL-10 locus, additional polymorphisms were genotyped. The results reveal that association of the IL-10 gene with restenosis is independent of flanking genes. Our findings demonstrate that IL-10 is associated with restenosis and therefore support the hypothesis that anti-inflammatory genes also may be involved in developing restenosis. Furthermore, they may provide a new targeting gene for drug-eluting stents.
Subject
Health
Biomedical Research
alanine
clopidogrel
cysteine
glycine
interleukin 10
ticlopidine
adult
aged
article
cardiovascular risk
confidence interval
controlled study
coronary artery bypass graft
disease marker
DNA flanking region
DNA microarray
drug eluting stent
female
gene linkage disequilibrium
gene locus
genetic association
genetic polymorphism
genetic predisposition
genetic risk
genetic variability
genotype
heart infarction
human
hypothesis
in-stent restenosis
major clinical study
male
pathogenesis
percutaneous coronary intervention
priority journal
risk factor
3' Untranslated Regions
Aged
Angioplasty, Transluminal, Percutaneous Coronary
Coronary Restenosis
Female
Genetic Predisposition to Disease
Genotype
Humans
Inflammation
Interleukin-10
Male
Middle Aged
Polymorphism, Genetic
Promoter Regions (Genetics)
Prospective Studies
Risk Factors
Treatment Outcome
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http://resolver.tudelft.nl/uuid:2cfa5e68-4355-4e04-9f69-c0b0c996b0a8
DOI
https://doi.org/10.1038/sj.gene.6364343
TNO identifier
239819
ISSN
1466-4879
Source
Genes and Immunity, 8 (1), 44-50
Document type
article