Title
Serum carotenoids and vitamins in relation to markers of endothelial
Author
van Herpen-Broekmans, W.
Klöpping-Ketelaars, I.
Michiel, B.
Cornelis, K.
Hans, P.
Hendriks, F.J.
Tijburg, L.
van Poppel, G.
Kardinaal, A.
TNO Preventie en Gezondheid
Publication year
2004
Abstract
Background: Endothelial cell dysfunction may be related to an increase in cellular oxidative stress. Carotenoids and vitamins could have an antioxidant-mediated tempering influence on endothelial function and inflammation, thereby reducing the risk of atherosclerosis. Methods: We measured serum carotenoids, α-tocopherol and Vitamin C concentrations in 379 subjects sampled from the general population. High-sensitive C-reactive protein (CRP), fibrinogen (Fbg) and leukocytes were measured as markers of inflammation. Furthermore, soluble intercellular adhesion molecule-1 (sICAM-1) and flow-mediated vasodilation (FMD; n=165) were measured as markers of endothelial function. Relationships between serum carotenoids and vitamins and markers of endothelial function and inflammation were analysed after adjustment for confounding. Results: In the total study group, lutein and lycopene were inversely related to sICAM-1 with regression-coefficients of -0.38 ± 0.19 (p=0.04) and -0.16 ± 0.08 (p=0.04) per 1 μmol/l, respectively. β-Carotene was inverse related to leukocytes (-0.23 ± 0.07; p=0.007) and CRP (-1.09 ± 0.30; p=0.0003) per 1 μmol/l. Vitamin C was inverse related to CRP (-0.01 ± 0.005; p=0.04) per 1 μmol/l, whereas α-tocopherol was positively related to CRP (0.03 ± 0.01; p=0.02) per 1 μ/l. Zeaxanthin was inversely related to FMD (31.2 ± 15.3; p=0.04) per 1 μmol/l. Conclusion: The inverse relations between carotenoids, Vitamin C and sICAM-1, CRP and leukocytes may help to explain the possible protective effect of carotenoids and Vitamin C on atherosclerosis through an influence on inflammatory processes and endothelial function.
Subject
Nutrition Health
Physiological Sciences
Carotenoids
Endothelial function
Inflammation
Vitamins
Alpha tocopherol
Ascorbic acid
Beta carotene
Beta cryptoxanthin
C reactive protein
Carotenoid
Intercellular adhesion molecule 1
Lycopene
Unclassified drug
Zeaxanthin
Blood flow
Disease marker
Inflammation
Leukocyte
Population research
Vascular endothelium
Vasodilatation
Vitamin blood level
Adult
Alpha-Tocopherol
Ascorbic Acid
Beta Carotene
Biological Markers
C-Reactive Protein
Carotenoids
Cross-Sectional Studies
Endothelium, Vascular
Female
Fibrinogen
Humans
Intercellular Adhesion Molecule-1
Male
Middle Aged
Smoking
Xanthophylls
To reference this document use:
http://resolver.tudelft.nl/uuid:2c461140-d17d-431d-95ed-7b223beb43c0
DOI
https://doi.org/10.1007/s10654-004-5760-z
TNO identifier
238045
ISSN
0393-2990
Source
European Journal of Epidemiology, 19 (10), 915-921
Document type
article