Title
A genetic association study of the IGF-1 gene and radiological osteoarthritis in a population-based cohort study (the Rotterdam study)
Author
Gaubius Instituut TNO
Meulenbelt, I.
Bijkerk, C.
Miedema, H.S.
Breedveld, F.C.
Hofman, A.
Valkenburg, H.A.
Pols, H.A.P.
Slagboom, P.E.
van Duijn, C.M.
Publication year
1998
Abstract
Objective - A genetic association study was performed to investigate whether radiographical osteoarthritis (ROA) was associated with specific genotypes of the insulin-like growth factor I (IGF-1) gene. Methods - Subjects aged 55-65 years were selected from a population-based study of which ROA at the knee, hip, spine, and hand was assessed. Genotypes were determined of a polymorphism in the promoter region of the IGF-1 gene. Results - The IGF-1 locus was significantly associated with the presence of ROA (overall adjusted OR for heterozygous subjects = 1.9, 95% CI 1.2, 3.1 and for homozygous subjects 3.6, 95% CI 0.8, 16.2). Conclusion - These results suggest that variation at the IGF-1 locus is associated with ROA development and may play a part in ROA pathogenesis. To confirm these findings replication in another population-based sample is needed.
Subject
Aged
Alleles
Body Mass Index
Bone Density
Female
Genotype
Humans
Insulin-Like Growth Factor I
Male
Middle Aged
Osteoarthritis
Prospective Studies
To reference this document use:
http://resolver.tudelft.nl/uuid:26759061-efa3-403a-ac0e-deb7613ba191
DOI
https://doi.org/10.1136/ard.57.6.371
TNO identifier
234590
ISSN
0003-4967
Source
Annals of the Rheumatic Diseases, 57 (57), 371-374
Document type
article