Title
Applying the exposome concept to working life health: The EU EPHOR project
Author
Pronk, A.
Loh, M.
Kuijpers, E.
Albin, M.
Selander, J.
Godderis, L.
Ghosh, M.
Vermeulen, R.
Peters, S.
Sivesind Mehlum, I.
Turner, M.
Schlunssen, V.
Goldberg, M.
Kogevinas, M.
Harding, B.
Solovieva, S.
Garani-Papadatos, T.
van Tongeren, M.
Stierum, R.
Publication year
2022
Abstract
Exposures at work have a major impact on noncommunicable diseases (NCDs). Current risk reduction policies and strategies are informed by existing scientific evidence, which is limited due to the challenges of studying the complex relationship between exposure at work and outside work and health. We define the working life exposome as all occupational and related nonoccupational exposures. The latter includes nonoccupational exposures that may be directly or indirectly influenced by or interact with the working life of the individual in their relation to health. The Exposome Project for Health and Occupational Research aims to advance knowledge on the complex working life exposures in relation to disease beyond the single high exposure-single health outcome paradigm, mapping and relating interrelated exposures to inherent biological pathways, key body functions, and health. This will be achieved by combining (1) large-scale harmonization and pooling of existing European cohorts systematically looking at multiple exposures and diseases, with (2) the collection of new high-resolution external and internal exposure data. Methods and tools to characterize the working life exposome will be developed and applied, including sensors, wearables, a harmonized job exposure matrix (EuroJEM), noninvasive biomonitoring, omics, data mining, and (bio)statistics. The toolbox of developed methods and knowledge will be made available to policy makers, occupational health practitioners, and scientists. Advanced knowledge on working life exposures in relation to NCDs will serve as a basis for evidence-based and cost-effective preventive policies and actions. The toolbox will also enable future scientists to further expand the working life exposome knowledge base. © 2022 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The Environmental Epidemiology. All rights reserved.
Subject
Exposome
Noncommunicable disease
Occupational
Working life
biological marker
biomaterial
biological monitoring
biostatistics
cohort analysis
cost effectiveness analysis
data mining
health impact assessment
human
information storage
medical research
night shift
occupational exposure
occupational health
omics
questionnaire
scientist
social status
stakeholder engagement
work
To reference this document use:
http://resolver.tudelft.nl/uuid:22632631-bed7-484e-922f-b68d9b6e8a9e
DOI
https://doi.org/10.1097/ee9.0000000000000185
TNO identifier
967461
Source
Environmental Epidemiology, 6 (6), E185
Document type
article