Title
Personalised nutrition: Status and perspectives
Author
TNO Kwaliteit van Leven
Joost, H.G.
Gibney, M.J.
Cashman, K.D.
Görman, U.
Hesketh, J.E.
Mueller, M.
van Ommen, B.
Williams, C.M.
Mathers, J.C.
Publication year
2007
Abstract
Personalised, genotype-based nutrition is a concept that links genotyping with specific nutritional advice in order to improve the prevention of nutrition-associated, chronic diseases. This review describes the current scientific basis of the concept and discusses its problems. There is convincing evidence that variant genes may indeed determine the biological response to nutrients. The effects of single-gene variants on risk or risk factor levels of a complex disease are, however, usually small and sometimes inconsistent. Thus, information on the effects of combinations of relevant gene variants appears to be required in order to improve the predictive precision of the genetic information. Furthermore, very few associations between genotype and response have been tested for causality in human intervention studies, and little is known about potential adverse effects of a genotype-derived intervention. These issues need to be addressed before genotyping can become an acceptable method to guide nutritional recommendations. © The Authors 2007.
Subject
Biomedical Research
Disease risk
Nutrigenetics
Nutrigenomics
Nutritional recommendations
Acyltransferase
Glutathione transferase
Xenobiotic agent
Carcinogenesis
Cholesterol metabolism
Diabetes mellitus
Dietary intake
Environmental factor
Familial hyperlipemia
Food composition
Gene interaction
Gene mutation
Genetic counseling
Genetic heterogeneity
Genetic screening
Genetic variability
Genotype phenotype correlation
Hypercholesterolemia
Hypertension
Mental deficiency
Nonhuman
Nutrient supply
Nutrigenomics
Nutritional assessment
Nutritional status
Nutritional value
Risk benefit analysis
Risk factor
Risk reduction
Single nucleotide polymorphism
Chronic Disease
Food
Genotype
Humans
Models, Genetic
Nutrition Disorders
Nutrition Physiology
Nutritional Requirements
Research
To reference this document use:
http://resolver.tudelft.nl/uuid:222e606d-a596-483b-9689-eeeacd977ca7
DOI
https://doi.org/10.1017/s0007114507685195
TNO identifier
240068
ISSN
0007-1145
Source
British Journal of Nutrition, 98 (98), 26-31
Document type
article