Print Email Facebook Twitter Four-week oral toxicity study with erythritol in rats Title Four-week oral toxicity study with erythritol in rats Author Til, H.P. Modderman, J. TNO Voeding Publication year 1996 Abstract Erythritol was orally administered to Wistar rats at dietary levels of 0, 5, and 10% for 4 weeks. Soft stools and diarrhea were observed in male and female animals of the 10% group and in female animals of the 5% group. These symptoms disappeared during the course of the study. Mean body weights of male rats in the high-dose group were significantly lower than those of controls during the course of the study. No such differences were observed in females. Small statistically significant changes in certain hematological, clinical chemistry, and urine parameters were noted in the high-dose group but were judged not to be biologically important. Weights of the cecum were increased relative to those of the controls. No treatment-related histological changes were observed. No ill effects, other than early diarrhea, were observed from erythritol levels at 5 or 10% in the diet. Based on these results, it was concluded that the feeding of erythritol at a dietary level of 10% did not result in toxicologically significant effects. Subject Toxicologyerythritolanimal experimentarticlebody weightcecumcontrolled studydiarrheadrug toxicityfemalehistologymalenonhumanorgan weightpriority journalratAdministration, OralAnimalsBody WeightDose-Response Relationship, DrugDrinkingDrug Administration ScheduleEatingErythritolFemaleMaleOrgan SizePotassiumRatsRats, WistarSodiumSweetening AgentsAnimaliaRattus norvegicus To reference this document use: http://resolver.tudelft.nl/uuid:1f3391ac-446b-4437-99c4-06f99ae35233 DOI https://doi.org/10.1006/rtph.1996.0101 TNO identifier 233709 ISSN 0273-2300 Source Regulatory Toxicology and Pharmacology, 24 (2 II) Document type article Files To receive the publication files, please send an e-mail request to TNO Library.