Efficacy, safety and novel targets in cardiovascular disease

Title

Efficacy, safety and novel targets in cardiovascular disease: advanced applications in APOE*3-Leiden.CETP mice

 Author

Pouwer, M.G.

Publication year

2020

 Abstract

The thesis discussed several strategies that may contribute to further CVD risk reduction in the future. We described two novel lipid-lowering strategies, we unraveled (part of) the etiology of the cardiovascular safety issues of TKIs that are used for the treatment of CML, and we investigated the dose effects of PFOA on lipoprotein metabolism. Looking forward, we developed a novel mouse model that can be used for the study of diabetic macrovascular complications, and we evaluated the potential of OSM as novel target in CVD.

 Subject

Atherosclerosis
Cholesterol
Lipoprotein metabolism
PFOA
PCSK9
BCR-ABL1 Tyrosine kinase inhibitors
Cardiovascular safety
Oncostatin M
Cardiovascular Disease
Translational mouse models
Biomedical Innovation
Healthy Living
Life
MHR - Metabolic Health Research
ELSS - Earth, Life and Social Sciences

 To reference this document use:

http://resolver.tudelft.nl/uuid:1ee32c99-6b28-4d7d-968e-34046ede847a

 TNO identifier

875205

 Publisher

Universiteit, Leiden

 ISBN

9789402816396

 Document type

doctoral thesis
Files
PDF pouwer-2020-efficiency.pdf