Title
Is Candida albicans a trigger in the onset of coeliac disease?
Author
Nieuwenhuizen, W.F.
Pieters, R.H.H.
Knippels, L.M.J.
Jansen, M.C.J.F.
Koppelman, S.J.
Publication year
2003
Abstract
Coeliac disease is a T-cell-mediated autoimmune disease of the small intestine that is induced by ingestion of gluten proteins from wheat, barley, or rye. We postulate that Candida albicans is a trigger in the onset of coeliac disease. The virulence factor of C albicans - hyphal wall protein 1 (HWP1) - contains aminoacid sequences that are identical or highly homologous to known coeliac disease-related α-gliadin and γ-gliadin T-cell epitopes. HWP1 is a transglutaminase substrate, and is used by C albicans to adhere to the intestinal epithelium. Furthermore, tissue transglutaminase and endomysium components could become covalently linked to the yeast. Subsequently, C albicans might function as an adjuvant that stimulates antibody formation against HWP1 and gluten, and formation of autoreactive antibodies against tissue transglutaminase and endomysium.
Subject
Biology Toxicology
Food technology
autoantibody
blood clotting factor 13a
epitope
gliadin
gluten
hyphal wall protein 1
protein glutamine gamma glutamyltransferase
unclassified drug
virulence factor
amino acid sequence
antibody production
article
autoimmune disease
Candida albicans
candidiasis
celiac disease
covalent bond
enzyme activity
genetic predisposition
human
immunoreactivity
intestine epithelium
intestine flora
nonhuman
pathophysiology
priority journal
protein expression
sequence analysis
sequence homology
Antibody Formation
Candida albicans
Celiac Disease
Fungal Proteins
Genetic Predisposition to Disease
Gliadin
Humans
Intestinal Mucosa
Membrane Glycoproteins
Transglutaminases
Virulence
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DOI
https://doi.org/10.1016/s0140-6736(03)13695-1
TNO identifier
237150
ISSN
0140-6736
Source
Lancet, 361 (9375), 2152-2154
Document type
article