Title
Safety profile of Hoodia gordonii extract: Rabbit prenatal developmental toxicity study
Author
Dent, M.P.
Wolterbeek, A.P.M.
Russell, P.J.
Bradford, R.
Publication year
2012
Abstract
Hoodia gordonii extract was orally administered by gavage to groups of 22 female New Zealand white rabbits from day 3-28 after mating at doses of 0 (control), 3, 6 or 12. mg/kg bodyweight/day. These doses were reached by a dose escalation phase between days 3 and 7 after mating. As well as a vehicle control group, a control group pair-fed to the high dose was also included. On day 29 after mating the females were euthanized and examined. Treatment at 6 or 12. mg/kg/day was associated with a dose-related reduction in feed intake and bodyweight gain. Feed consumption and bodyweight gain was unaffected at 3. mg/kg/day. In spite of marked maternal effects at 12. mg/kg/day, reproductive indices were unaffected at all doses and there were no effects on fetal or placental weights and no morphological changes in the fetuses. The no-observed-effect level (NOEL) for developmental effects was therefore 12. mg/kg/day, and the maternal NOEL was 3. mg/kg/day. At doses that caused marked maternal effects, H. gordonii extract did not affect embryonic or fetal development in a species that is considered predictive of developmental toxicity in man. © 2011 Elsevier Ltd.
Subject
Life
QS - Quality & Safety
EELS - Earth, Environmental and Life Sciences
Research
Healthy Living
Embryo-fetal development
Food safety
Functional food
Hoodia gordonii
Plant extract
Steroid glycosides
To reference this document use:
http://resolver.tudelft.nl/uuid:1659c5f0-e945-40f7-90ff-1fbfc40f883c
DOI
https://doi.org/10.1016/j.fct.2011.04.008
TNO identifier
447268
ISSN
0278-6915
Source
Food and Chemical Toxicology, 50 (SUPPL. 1), S26-S33
Document type
article