Title
The serosal immune system of the thorax in toxicology
Author
Kuper, C.F.
van Bilsen, J.
Wijnands, M.V.W.
Publication year
2018
Abstract
The thoracic cavities receive increasing attention in toxicology, because inhaled fibers and (nano)particles can reach these cavities and challenge the local lymphoid tissues. The thoracic and abdominopelvic cavities are controlled by the serosal immune system with its special, loosely organized lymphoid clusters, namely the fat-associated lymphoid clusters andmilky spots, which together can be denoted as serosa-associated lymphoid clusters. These clusters house numerous innate lymphoid cells, namely the nonconventional, innate B lymphoid cell and innate lymphocyte type 2 populations. The fat depots in the thorax play a significant role in the serosal immunity, and they can bemodulated by health issues such as metabolic syndrome. The serosal immune systemoperates in a unique way at the interface of the innate and acquired immunity and therefore exposure-relatedmodulation of the systemmay have a distinct impact on the body's immunity. To add to the investigation of the serosal immune systemin the thorax, this review describes the (micro)anatomy of the immune system in relation to exposure, with a focus on the rat andmouse as preferred species in toxicology and immunology. © The Author(s) 2018. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved.
Subject
Toxicology
Fat-associated lymphoid clusters
Innate lymphoid cells
Mediastinum
Milky spots
Pleura
Serosa-associated lymphoid clusters
B lymphocyte
Cell structure exposure
Human
Immune system
Innate immunity
Intra-abdominal fat
Lymphocyte subpopulation
Lymphoid cell
Mesothelium
Metabolic syndrome X
Nonhuman
Ontogeny
Pleura cavity
Serosa
Thoracic cavity
Thorax
Toxicology
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DOI
https://doi.org/10.1093/toxsci/kfy085
TNO identifier
842160
ISSN
1096-6080
Source
Toxicological Sciences, 164 (1), 31-38
Document type
article