Title
Genome-wide association of major depression: Description of samples for the GAIN Major Depressive Disorder Study: NTR and NESDA biobank projects
Author
Boomsma, D.I.
Willemsen, G.
Sullivan, P.F.
Heutink, P.
Meijer, P.
Sondervan, D.
Kluft, C.
Smit, G.
Nolen, W.A.
Zitman, F.G.
Smit, J.H.
Hoogendijk, W.J.
van Dyck, R.
de Geus, E.J.C.
Penninx, B.W.J.H.
TNO Kwaliteit van Leven
Publication year
2008
Abstract
To identify the genomic regions that confer risk and protection for major depressive disorder (MDD) in humans, large-scale studies are needed. Such studies should collect multiple phenotypes, DNA, and ideally, biological material that allows gene expression analysis, transcriptomic, proteomic, and metabolomic studies. In this paper, we briefly review linkage studies of MDD and then describe the large-scale nationwide biological sample collection in Dutch twin families from the Netherlands Twin Register (NTR) and in participants in the Netherlands Study of Depression and Anxiety (NESDA). Within these studies, 1862 participants with a diagnosis of MDD and 1857 controls at low liability for MDD have been selected for genome-wide genotyping by the US Foundation for the National Institutes of Health Genetic Association Information Network. Stage 1 genome-wide association results are scheduled to be accessible before the end of 2007. Genome-wide association results are open-access and can be viewed at the dbGAP web portal (http://www.ncbi.nlm.nih.gov). Approved users can download the genotype and phenotype data, which have been made available as of 9 October 2007.
Subject
Healthy for Life
Health
Healthy Living
adult
anxiety disorder
article
controlled study
depression
diagnostic and statistical manual of mental disorders
dizygotic twins
DNA isolation
female
genetic analysis
genetic association
genotype
human
linkage analysis
major clinical study
major depression
male
Netherlands
onset age
phenotype
priority journal
Cohort Studies
Depressive Disorder, Major
Genome, Human
Humans
Linkage (Genetics)
Longitudinal Studies
To reference this document use:
http://resolver.tudelft.nl/uuid:11ad1f1d-dcaa-479b-b995-6ce6bed6a48a
DOI
https://doi.org/10.1038/sj.ejhg.5201979
TNO identifier
240677
ISSN
1018-4813
Source
European Journal of Human Genetics, 16 (3), 335-342
Document type
article