Title
Therapeutic effects of Δ9-THC and modafinil in a marmoset Parkinson model
Author
TNO Defensie en Veiligheid
van Vliet, S.A.M.
Vanwersch, R.A.P.
Jongsma, M.J.
Olivier, B.
Philippens, I.H.C.H.M.
Publication year
2008
Abstract
Current therapies for Parkinson's disease (PD) like l-dopa and dopamine (DA) agonists have declined efficacy after long term use. Therefore, research towards supplementary or alternative medication is needed. The implementation in PD can be expedited by application of compounds already used in the clinic. In this study the therapeutic effects of the psychoactive compounds Δ9-tetrahydrocannabinol (Δ9-THC) and modafinil were tested in the 1-methyl-1,2,3,6-tetrahydropyridine (MPTP)-marmoset model for PD. The anti-parkinson effects of Δ9-THC (4 mg/kg) and modafinil (100 mg/kg) in parkinsonian marmosets were assessed with two behavioral rating scales covering parkinsonian symptoms and involuntary movements and two test systems assessing the locomotor activity and hand-eye coordination. Δ9-THC improved activity and hand-eye coordination, but induced compound-related side-effects. Modafinil improved activity and observed parkinsonian symptoms but not hand-eye coordination. It can be concluded that both compounds have therapeutic values and could supplement existing therapies for PD. © 2007 Elsevier B.V. and ECNP.
Subject
Behavior
Delta-9-tetrahydrocannabinol
Hand-eye coordination
Locomotor activity
Marmoset
Modafinil
MPTP
Parkinson's disease
Therapy
1,2,3,6 tetrahydro 1 methyl 4 phenylpyridine
Antiparkinson agent
Dopamine receptor stimulating agent
Dronabinol
Levodopa
Modafinil
Psychotropic agent
Benzhydryl derivative
Tetrahydrocannabinol
Animal behavior
Animal experiment
Animal model
Controlled study
drug effect
Dxploratory behavior
Eye hand coordination
Female
Involuntary movement
Locomotion
Male
Marmoset
Nonhuman
Parkinson disease
Rating scale
Single drug dose
Symptom
Animal
Chemically induced disorder
Disease model
Parkinsonism
Pathophysiology
Antiparkinson agents
Benzhydryl compounds
Callithrix
Female
Parkinsonian disorders
Tetrahydrocannabinol
1,2,3,6 tetrahydro 1 methyl 4 phenylpyridine, 28289-54-5
Dronabinol, 7663-50-5;
Levodopa, 59-92-7
Modafinil, 68693-11-8
Tetrahydrocannabinol, 1972-08-3
Antiparkinson agents
Benzhydryl compounds
To reference this document use:
http://resolver.tudelft.nl/uuid:0c4581c6-8638-46ae-878c-3693ccc857fe
DOI
https://doi.org/10.1016/j.euroneuro.2007.11.003
TNO identifier
183573
ISSN
0924-977X
Source
European Neuropsychopharmacology, 18 (18), 383-389
Document type
article