Title
Toxicity of terpenes to spores and mycelium of Penicillium digitatum
Author
Wolken, W.A.M.
Tramper, J.
van der Werf, M.J.
Centraal Instituut voor Voedingsonderzoek TNO
Publication year
2002
Abstract
Spores, although often considered metabolically inert, catalyze a variety of reactions. The use of spores instead of mycelium for bioconversions has several advantages. In this paper, we describe the difference in susceptibility of mycelium and spores against toxic substrates and products. A higher resistance of spores toward the toxic effects of bioconversion substrates and products is an advantage that has not been studied in detail until now. This paper shows that spores of Penicillium digitatum ATCC 201167 are on average over 2.5 times more resistant than mycelium toward the toxicity of substrates, intermediates, and products of the geraniol bioconversion pathway. Furthermore, the higher resistance of spores to citral was shown as an advantage in its biotransformation by P. digitatum. Using three different approaches the toxicity of the compounds were tested. The order of toxicity toward P. digitatum was, starting with the most toxic, citral > nerol/geraniol > geranic acid > methylheptenone ≫ acetaldehyde. © 2002 Wiley Periodicals, Inc. Chemicals/CAS: citral, 5392-40-5; Monoterpenes; Terpenes
Subject
Nutrition
Biotransformation
Cell Division
Colony Count, Microbial
Dose-Response Relationship, Drug
Lethal Dose 50
Monoterpenes
Mycelium
Penicillium
Sensitivity and Specificity
Species Specificity
Spores, Fungal
Terpenes
To reference this document use:
http://resolver.tudelft.nl/uuid:021c12e0-d7b8-4d89-9739-2717e000325f
DOI
https://doi.org/10.1002/bit.10435
TNO identifier
57620
ISSN
0006-3592
Source
Biotechnology and Bioengineering, 80 (6), 685-690
Document type
article